Eliminating x=−21−y−z gives (x−y)(x−z)+81=(2y+z+21)(y+2z+21)+81=81(4y+4z+1)2+(y+21)(z+21). Since y+21≥0 and z+21≥0, the right-hand side is non-negative, so (x−y)(x−z)≥−81. Equality holds if and only if 4y+4z+1=0 and (y+21)(z+21)=0, i.e. x=−41 and {y,z}={−21,41}.